EMA has recommended the granting of marketing authorisationsfor two new antiretroviral (ARV) medicines, Rekambys (rilpivirine) and Vocabria injection (cabotegravir), to be used together for the treatment of patients with human immunodeficiency virus type 1 (HIV-1) infection. Marketing Authorisation is based on the pivotal phase III ATLAS (Antiretroviral Therapy as Long-Acting Suppression), FLAIR (First Long-Acting Injectable Regimen) and ATLAS-2M studies, which included more than 1,200 participants from 16 countries. USA.gov. HHS More information: S. Rahima Benhabbour et al. and, for the combination of the long-acting rilpivirine and cabotegravir, provides an additional two-drug ART option. EDURANT® (rilpivirine) is a once daily non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of human immunodeficiency virus (HIV-1) infection in combination with other antiretroviral agents in antiretroviral treatment-naïve patients 12 years of age and older and weighing at least 35-kg with a viral load ≤ 100,000 HIV RNA copies/mL. Two clinical trials of long-acting injectable cabotegravir and rilpivirine showed promising safety, efficacy, and tolerability as maintenance ART. Author information: … 2019 Oct;311-312:201-211. doi: 10.1016/j.jconrel.2019.09.001. Epub 2020 Jun 15. Kevadiya BD, Ottemann B, Mukadam IZ, Castellanos L, Sikora K, Hilaire JR, Machhi J, Herskovitz J, Soni D, Hasan M, Zhang W, Anandakumar S, Garrison J, McMillan J, Edagwa B, Mosley RL, Vachet RW, Gendelman HE. Based on the results of the phase 3 efficacy studies called ATLAS and FLAIR, we know that injectable CAB/RPV is safe, well-tolerated, and (among those who chose to participate in the studies), highly popular. 2020 Dec 5;133(23):2775-2777. doi: 10.1097/CM9.0000000000001226. J Subst Abuse Treat. NLM Hilaire JR, Bade AN, Sillman B, Gautam N, Herskovitz J, Dyavar Shetty BL, Wojtkiewicz MS, Szlachetka A, Lamberty BG, Sravanam S, Fox HS, Alnouti Y, Dash PK, McMillan JM, Edagwa BJ, Gendelman HE. Read on to learn more about the new drug and what to consider ahead of its potential arrival in early 2021. Investigators presented a case report of a second patient possibly cured of HIV through an allogeneic hematopoietic stem cell transplant from a CC chemokine receptor 5-delta 32 donor. Long-acting injectable rilpivirine is not approved by … Awareness about and willingness to use long-acting injectable pre-exposure prophylaxis (LAI-PrEP) among people who use drugs. This strategy — two injections every 4 or 8 weeks — obviates the need to take antiretroviral therapy daily. Hilaire JR, Bade AN, Sillman B, Gautam N, Herskovitz J, Dyavar Shetty BL, Wojtkiewicz MS, Szlachetka A, Lamberty BG, Sravanam S, Fox HS, Alnouti Y, Dash PK, McMillan JM, Edagwa BJ, Gendelman HE. Advances and challenges in antiretroviral therapy for acquired immunodeficiency syndrome. COVID-19 is an emerging, rapidly evolving situation. The 2019 Conference on Retroviruses and Opportunistic Infections included many exciting advances in antiretroviral therapy (ART). 2012 Jun-Jul;20(2):61-86. “ We found that long-acting injectable antiretroviral therapy was a compelling option among the women we interviewed.” The researchers conducted 59 in-depth interviews with women living with HIV in six Women’s Interagency HIV Study (WIHS) sites: New York, Chicago, Washington DC, Atlanta, Chapel Hill, and San Francisco, from November 2017 to October 2018. Rod-shape theranostic nanoparticles facilitate antiretroviral drug biodistribution and activity in human immunodeficiency virus susceptible cells and tissues. Long-acting injectable antiretroviral therapy (ART) offers the convenience of reduced dosing frequency and, for the combination of the long-acting rilpivirine and cabotegravir, provides an additional two-drug ART option. CROI 2014: Advances in antiretroviral therapy. CROI 2014: Advances in antiretroviral therapy. Epub 2019 Sep 3. In FLAIR, people who were treatment-naive were started on abacavir/dolutegravir/lamivudine (Triumeq) and, if they achieved viral suppression at 20 weeks, were randomized to either stay on this oral regimen or add oral CAB and RPV (to demonstrate …  |  Antiretroviral therapy interrupts crucial steps of the HIV life cycle. Antiretroviral Therapy in 2019: Which Is the Best Regimen for the Global Roll-Out? HHS CROI 2018: Advances in Antiretroviral Therapy. Epub 2020 Jun 15. Emerging alternative antiretroviral (ARV) delivery systems for HIV treatment and prevention include injectables, topicals, and implants. They had been on antiretroviral therapy for a median of four years, all had viral suppression and the median CD4 count was 653 cells/mm3. Investigators presented a case report of a second patient possibly cured of HIV through an allogeneic hematopoietic stem cell transplant from a CC chemokine receptor 5-delta 32 donor. Please enable it to take advantage of the complete set of features! [Epub ahead of print] A Conjoint Analysis of the Acceptability of Targeted Long-Acting Injectable Antiretroviral Therapy Among Persons Living with HIV in the U.S. Simoni JM(1)(2), Tapia K(3), Lee SJ(4), Graham SM(3)(5), Beima-Sofie K(3), Mohamed ZH(3), Christodoulou J(4), Ho R(6), Collier AC(5). Test-and-treat and rapid-ART-start strategies show promise in advancing progress toward the HIV care cascade 90-90-90 Joint United Nations Programme on HIV/AIDS/World Health Organization targets. Test-and-treat and rapid-ART-start strategies show promise in advancing progress toward the HIV care cascade 90-90-90 Joint United Nations Programme on HIV/AIDS/World Health Organization targets. In vitro studies were presented that identified and evaluated the effect of resistance-associated mutations on ART susceptibility and elucidated mechanisms of resistance. 2020 Jan 1;10(2):630-656. doi: 10.7150/thno.39847. Epidemiologic data were reported on the prevalence, impact, regional variation, and changes over time of resistance-associated mutations. Long-acting (LA) injectable antiretroviral therapy (ART) has been found non-inferior to daily oral ART in Phase 3 trials. Would you like email updates of new search results? National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Chin Med J (Engl). Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. 2016 May-Jun;24(1):59-81. To date, women have been less represented than men in LA ART research. Olender S, Wilkin TJ, Taylor BS, Hammer SM. The data supporting a regimen consisting of injectable CAB/RPV were presented at CROI 2019 in the form of a pair of open-label trials named FLAIR and ATLAS.  |  CROI 2016: Advances in Antiretroviral Therapy. More information: Morgan M. Philbin et al, A Qualitative Exploration of Women's Interest in Long-Acting Injectable Antiretroviral Therapy Across … 2020 Oct;117:108058. doi: 10.1016/j.jsat.2020.108058. 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